[PackGene Biotech 한국공식대리점] AAV Packaging Services

어스바이오는 PackGene Biotech 한국 공식 대리점으로서 모든 제품을 전문적으로 취급 및 공급하고 있습니다.
PackGene Biotech의 AAV Packaging Services를 소개드립니다.
 

PackGene Biotech은 독자적 생산 플랫폼과 최적화된 세포주, 개선된 플라스미드를 통해 AAV 생산량을 극대화하며, 70종 이상의 AAV 혈청형을 고역가·고순도·고활성으로 제공하고 있습니. 연구·NHP·HT-grade 전임상용부터 임상용 GMP-grade AAV 제조까지 지원하여 안정적이고 일관된 유전자 치료 개발을 가능하게 합니다.
 

PackGene AAV Packaging Service
	Research Grade	NHP Grade	HT Grade
Application	Cell culture, small animal	Small animal or non-human primates	Cell culture
Scale	2E+12 ~ 8E+14 GC	1E+13 ~ 1E+16	2E+11 ~ 2E+13 GC
Lead time	Start from 12 business days	Start from 17 business days	7-14 business days
QC test	qPCR, SDS-PAGE Coomassie Blue Staining, endotoxin LAL, plasmid restriction enzyme digestion	ddPCR, SDS-PAGE Silver Staining, endotoxin LAL, plasmid restriction enzyme digestion	qPCR
Performance Comparison
Titration	qPCR, Titer meet requirements	ddPCR, Titer meet requirements	qPCR, Titer meet requirements
AAV purity analysis	SDS-PAGE, Coomassie Blue Staining, Capsid band size meet reference	SDS-PAGE, Silver Staining, Capsid band size meet reference, Capsid band size meet reference	-
Endotoxin Test	LAL, <10EU/mL	LAL, <1EU/ml (endotoxin removal may reach <0.2EU/ml)	-
Mycoplasma	-	qPCR, Negative	-
Bioburden	-	48 hr, no growth	-
AAV Genome integrity	-	Capillary Electrophoresis, report value	-
Empty Capsid	TEM, guaranteed empty capsid rate <30% for common serotypes	TEM, guaranteed empty capsid rate <20% for common serotypes	-
TEM images

 

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